Immunomodulatory Effects of Blood Transfusion

  • 296 Pages
  • 1.80 MB
  • English

S Karger Pub
Pharmacology, Hematology, Immunology, Blood Transfusion, Immunosuppressive Agents, Me
ContributionsEleftherios C. Vamvakas (Editor), Morris A. Blajchman (Editor)
The Physical Object
ID Numbers
Open LibraryOL12931134M
ISBN 103805570570
ISBN 139783805570572

Immunomodulatory Effects of Blood Transfusion by Eleftherios C. Vamvakas (Author), Morris A.

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Blajchman (Author) ISBN Cited by: ISBN: X: OCLC Number: Description: xiv, pages: illustrations: Responsibility: [edited by] Eleftherios C. Vamvakas, Morris A. The effects of blood transfusion on the functions of the immune system have been studied in humans and laboratory animals for more than 25 years.

It is becoming customary to refer to these effects on the immune system as “immunomodulatory,” as they may involve augmentation as well as suppression of elements of the immune by: Immunomodulatory and Proinflammatory Effects of Allogeneic Blood Transfusion.

Eleftherios C. Vamvakas MD, PhD. Book Editor(s): Toby L. Simon MD. Blood Transfusion Service, Massachusetts General Hospital, USA. Harvard Medical School, Boston, Massachusetts, USA Cited by: 3. Transfusion-related immunomodulation refers to the transient depression of the immune system following transfusion of blood products.

This effect has been recognized in groups of individuals who have undergone kidney transplantation or have had multiple miscarriages. Some research studies have shown that, because of this immune depression, blood transfusions increase the risk of infections and Blood group systems / blood types: ABO, Chido.

The immunomodulatory effects of blood transfusion. Klein HG(1). Author information: (1)Department of Transfusion Medicine, National Institutes of Health, Bethesda, MDUSA.

[email protected] by: 5. It also deals with transfusion transmitted diseases, different techniques for allotransplantation and immunomodulatory effects of blood transfusion. The book covers various aspects of blood transfusion and will provide valuable information to its readers. Background: One of the adverse effects of blood transfusion is the transfusion-related increased incidence of cancers is described as a main outcome of such immunomodulation.

The transfusion of various allogeneic blood components is circumstantially linked with subtle immunosuppressive effects. Whole blood transfusions may enhance renal allograft survival and reduce relapse rates of Crohn's disease. In some murine models tumor growth and bacterial infection can be increased by transfusion of fresh allogeneic whole blood, but not by that of prestorage leukocyte.

Transmission of disease(s) from the blood donor to the recipient and the transfusion-induced alloimmunization of the recipient BT-induced immunomodulatory effects, both beneficial and deleterious Beneficial effects in clinical organ transplantation and in treatment of Cited by: Immunomodulatory Effects of Transfusion David T.

Porembka T HE administration of blood and its compo- nents can be life-saving, particularly during resuscitation in trauma patients when blood loss can be severe enough to result in cellular hypoxia.1 Also, during other critical illness such as systemic inflammatory response syndrome, especially if the patient is septic with significant acute Cited by: 1.

Deleterious clinical effects of transfusion immunomodulation: Proven beyond a reasonable doubt Article Literature Review in Transfusion 45(2 Suppl)SS; discussion 39SS September Author: Neil Blumberg. Immunomodulatory Effects of Blood Transfusion Immunomodulatory Effects of Blood Transfusion Petz, Lawrence D.

The clinical significance of the immuno‐modulatory effects of blood transfusion and the question of whether universal WBC reduction should be instituted throughout the United States are being hotly debated at the present time.

Blood Transfusion in Clinical Practice focuses on the application of blood transfusion in different clinical settings. The text has been divided into five sections.

The first section includes a chapter describing the basic principles of ABO blood group system in blood transfusion. The second section discusses the use of transfusion in various clinical settings including orthopedics, obstetrics Cited by: 2.

Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available.

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It features brand new chapters on the measurement of cell kinetics, obstetric transfusion practice, cord blood, transfusion alternatives and regenerative medicine. The transfusion of blood in anemic patients should help in oxygen delivery to tissues but there is evidence that transfused blood fails to increase tissue oxygen utilization (Suttner et al., ).

In addition, the potential infectious, inflammatory and immunomodulatory effects of Cited by: 1. 45 Immunomodulatory and Proinflammatory Effects of Allogeneic Blood Tranfusion: Eleftherios C. Vamvakas, José O.

Bordin and Morris A. Blajchman. Part II. Infectious Hazards of Transfusion.

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46 Transfusion-Transmitted Hepatitis: Harvey J. Alter and Juan I. Esteban-Mur. 47 Retroviruses and Other Viruses: John A. Barbara and Brian Dow. Abstract. Allogeneic blood transfusion has been reported to cause immunomodulatory effects, which purportedly enhance the survival of renal allografts [1], increase the recurrence rate of resected malignancies [2–5], increase the frequency of postoperative bacterial infections [3,5,6–8], reduce the recurrence rate of Crohn’s disease [9], and/or accelerate the progression of human Author: E.

Vamvakas. Impact of Blood Transfusion on Short- and Long-Term Mortality in Patients With ST-Segment Elevation Myocardial Infarction Mehdi H. Shishehbor, Surabhi Madhwal, Vivek Rajagopal, Amy Hsu, Peter Kelly, Hitinder S.

Gurm, Samir R. Kapadia, Michael S. Lauer, Eric J. Topol We examined the short- and long-term outcomes of blood transfusion in 4, ST-segment elevation myocardial Cited by: Even though blood transfusion-associated immunomodulatory effects have been reported, the basic immune mechanism is still not understood.

Data from studies on the clinical effects of allogeneic blood-induced immunosuppression are by:   Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available.

It features brand new chapters on the measurement of cell kinetics, obstetric transfusion practice, cord blood, transfusion alternatives and regenerative medicine.

effects of transfusion may contribute to an increased incidence of tumor recurrence and infectious complications in surgical patients; however, the subject remains controversial.

Most of the immunomodulatory effects of transfusion demonstrable in vitro are mediated by white blood cells or soluble products derived from Size: 91KB. There are several difficulties assessing potential adverse effects of leukocytes as they may be responsible for a wide range of blood component quality and safety issues.

9 The presence of leukocytes has been shown to be responsible for specific adverse outcomes in some patients (e.g.

non-haemolytic febrile transfusion reaction, platelet. Adverse Effects of Blood Transfusion By Dr Consultant Blood Bank Alchemist Hospital Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.

Abstract. Purported deleterious effects of allogeneic transfusion-related immunomodulation (TRIM) have included increased recurrence of resected malignancies and of postoperative bacterial infections, increased short-term (up to 3-months post-transfusion) mortality from all causes, and activation of endogenous Cytomegalovirus or human immunodeficiency virus infection Author: Eleftherios C.

Vamvakas. When you receive BLOOD transfusions, you don't get much else besides red cells. We call it "blood" but it's really a "packed red blood cell transfusion." The packed cells are mixed with saline and infused.

You don't get meaningful amounts of anti. PRBC transfusion results in a variety of immunomodulatory effects, often referred to as transfusion-associated immunomodulation.

Numerous components of blood have been implicated as agents of transfusion-associated immunomodulation. The last section speculates over immunomodulatory effects of blood transfusion. Libro / Book 5to Curso Internacional de Anestesiología cardiotorácica, vascular, ecocardiografía y.

Immunotherapy or Biological therapy is the treatment of disease by activating or suppressing the immune therapies designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies.

In recent years, immunotherapy has become of great interest to researchers MeSH: D "FOR the life of the flesh is in the blood. No soul of you shall eat blood." So says the Bible's book of Leviticus, and it is for this reason that Jehovah's Witnesses shun blood transfusions.

• A mild short-term rise in temperature is one of the most common adverse effects of blood transfusion. The specific reason may not always be found.

A severe fever reaction may be a sign of bacterial contamination of the blood product, for example.A defined, hospital-specific MTP allows trained providers to recognize patients at risk of high-volume blood loss early, initiation of massive transfusion quickly, and has specific stop points to limit over transfusion.

We recommend that all centers that take care of critically ill patients of all varieties should evaluate the literature and Cited by: 3.Blood transfusion is a medical therapy that can be life-saving.

As with any treatment, however, transfusion of blood or blood components must be ordered and administered safely and appropriately. Transfusion is more than a single discrete event—it is a process. The transfusion chain begins with donor considerations (whether their donation is.