Regulation of CD4 T cell differentiation by OX40L

  • 212 Pages
  • 0.30 MB
  • English
University of Birmingham , Birmingham
Statementby Sarah Flynn.
The Physical Object
Pagination212p. :
ID Numbers
Open LibraryOL18580997M

Regulation of T Cell Immunity by OX40 and OX40L. , and. OX40 (CD) and its binding partner OXLigand (OX40L) represent members of the TNFR and TNF superfamilies that appear to be crucial to many types of immune reaction mediated by T Michael Croft, Shahram Salek-Ardakani, Jianxun Song, Takanori So, Pratima Bansal-Pakala.

Strikingly, specific blockade of OXOX40L interactions throughout the challenge period reduced the accumulation of CD4 T cells, and specifically CD4+/CD44 high OX40+ cells at all days examined, and almost completely suppressed the memory Th2 cell driven pulmonary inflammation.

Moreover, MLNs or lung cell cultures from mice where OX40L was blocked showed little reactivity with respect to antigen-specific proliferation and Th2 Cited by: The regulation of T cells and immunity by OX40 and BB have been reviewed extensively elsewhere [], with much of the early focus on these molecules concentrating around the idea that they primarily regulate effector-like CD4 or CD8 T cells that could be protective or pathogenic depending on the situation in which they arise.

Both OX40 and BB signal through TRAF adaptor molecules that are Cited by: OX40 (CD) and its binding partner OXLigand (OX40L) represent members of the TNFR and TNF superfamilies that appear to be crucial to many types of immune reaction mediated by T cells. Regulation of CD4 T cell memory by OX40 (CD) CD4 memory T cells play a critical role in protection against repeated exposure to infectious agents such as viruses, bacteria, and helminth parasites, yet can also contribute to the aberrant immune responses associated with autoimmune and allergic reactions.

OX40/OX40 Ligand Interactions in T-Cell Regulation and Asthma. The OX40 receptor is preferentially expressed by T cells, and its cognate ligand OX40L is primarily expressed by antigen-presenting cells such as dendritic cells following activation by thymic stromal lymphopoietin (TSLP).Cited by: OX40 and OX40L are Induced on Lymphoid and Non-lymphoid Cells.

OX40 (CD, TNFRSF4) was initially identified as a T cell activation marker and later after cloning shown to be a member of the NGFR/TNFR superfamily with costimulatory function ().OX40 can be induced on both activated CD4 and CD8 T cells, but is not found on resting naïve T cells or most resting memory T cells ().Cited by: This book will focus on the differentiation and regulation of subsets of CD4+ T cells.

It will also cover other aspects of research on these cells, which has made great advances in recent years, such as subsets’ plasticity and their role in healthy and disease conditions. The book provides. OX40 plays a key role in modulating the phenotypic differentiation from CD4 + T cells to DNT.

Because DNT conversion is APC dependent, we investigated the involvement of co-stimulation pathways in this process. B, B, CD40L- and OX40L-blocking Cited by: CD4+T Cells: Differentiation and Hindawi Publishing Corporation.

Clinical and Developmental Immunology. regulation of T cell responses, ” Imm unity,v o l.1 9,n o.5,p p. Regulation of CD4 T-cell differentiation and inflammation by repressive histone methylation Article (PDF Available) in Immunology and Cell Biology · January with 56 Reads How we measure 'reads'.

The question of how gene expression is regulated during differentiation is fundamental to many biological systems. In the immune system one of the most avidly studied lineage fate decisions is that occurring during the development of the mature CD4 + and CD8 + T-cell lineages. The CD4 and CD8 molecules act as surrogate markers for the specialized effector functions of mature T cells, as well Cited by: 6.

Multiple regulators of Th17 cell differentiation and IL production are reported, but the impact of OX40L is not described. OX40 ligand (OX40L) is an early-stage activator of T-cells through its interaction with CD (OX40) that is up-regulated on antigen challenged by: OX40L-mediated signaling induces B-cell activation and differentiation as well as IL production, but inhibits the generation and function of ILproducing CD4 + type 1 regulatory T cells ().

An SLE-risk haplotype defined by tag SNPs in the upstream region of TNFSF4 is identified using both case–control and family-based European-derived samples, which correlates with increased expression of OX40L. OX40 plays a role in CD4 + T-cell responses, as well as T cell–dependent B-cell proliferation and differentiation.

OX40L-mediated signaling induces B-cell activation and differentiation as well as IL production but inhibits the generation and function of IL–producing T-regulator cells.

Mar 31,  · Phyllis-Jean Linton, Beverly Bautista, Elana Biederman, Evan S. Bradley, Judith Harbertson, Robyn M.

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Kondrack, Ryan C. Padrick, Linda M. Bradley; Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In by: Figure 1. Regulation of cytotoxic CD4 T cell differentiation by a network of signaling and transcriptional is essential for the lineage specification and stability of CD4 helper T cells and counteracts Runx3, which coordinate the differentiation of CD8 T by: This suggests a sequential model of naive CD4 T cell activation with OX40 expression being dependent on an initial CD28 signal.

Subsequent activation of DCs through CD40 by CD4 T cell CD40L in turn upregulates DC OX40L. OX40 and CD28 signals are highly synergistic for CD4 T cell Cited by: Apr 01,  · Recent work shows that after stimulation with antigen, CD4 + and CD8 + T cells embark on a programme of proliferation that is closely linked with the acquisition of effector functions and leads Cited by: Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CDOX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting Aliases: TNFRSF4, ACT35, CD, IMD16, OX40.

OX40L is the ligand for OX40 (also known as CD or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells), macrophages, and activated B lymphocytes. The OX40 molecule, on the other hand, is present on the surface of activated T lymphocytes (mainly CD4+ T cells), HGNC: Feb 25,  · The other mechanism involves the provision of signals by CDb + DC that regulate LNs to maintain an optimal environment for the Th2 cell differentiation of antigen-specific CD4 + T cells.

Though mice encode both Clec10a and Mgl2, which are translated into CDa and CDb, respectively, humans do not have a gene that encodes by: RORγt is necessary for the generation of T H 17 cells but the molecular mechanisms for the regulation of T H 17 cells are still not fully understood.

We show that activation of CD4 + T cells results in the expression of inducible nitric oxide synthase (iNOS).

Details Regulation of CD4 T cell differentiation by OX40L FB2

iNOS-deficient mice displayed enhanced T H 17 cell differentiation but without major effects on either T H 1 or T H 2 cell lineages. Summary: OX40 (CD) and its binding partner, OX40L (CD), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily and are expressed on activated CD4 + and CD8 + T cells as well as on a number of other lymphoid and non‐lymphoid cells.

Costimulatory signals from OX40 to a conventional T cell promote division and survival, augmenting the clonal expansion of Cited by: Feb 01,  · Ligation of the TNF receptor family costimulatory molecule OX40 (CD) with an agonist anti-OX40 monoclonal antibody (mAb) enhances antitumor immunity by augmenting T-cell differentiation as well as turning off the suppressive activity of the FoxP3+CD4+ regulatory T cells (Treg).

In addition, antibody-mediated blockade of the checkpoint inhibitor CTLA-4 releases the “brakes” on T cells Cited by: Differentiation of naive CD4 T cells into specialized T helper (Th) We used an anti-OX40L blocking antibody during the TSLP-DC CD4 T cell co-culture.

OX40L blocking inhibited IL-3 secretion, Regulation of T follicular helper cell formation and function by antigen presenting cells. This book will focus on the differentiation and regulation of subsets of CD4+ T cells.

It will also cover other aspects of research on these cells, which has made great advances in recent years, such as subsets’ plasticity and their role in healthy and disease conditions.

Gene regulation in the differentiation of CD4+ and CD8+ T cells. [Amelie Collins; David Roth; Juan Lafaille; Gordon Fishell; Jane Skok; Richard Flavell] -- The mechanism of T-cell differentiation, by which precursor double positive thymocytes give rise to MHC class I-specific CD8+ T cytotoxic cells and MHC class II-specific CD4+ T helper cells, has been.

May 11,  · To better understand regulation of ILA secretion from human CD4 + T cells, we used a strategy that would allow us to evaluate the effects of various combinations of cytokine on expansion of T.

By assessing Th2 cell metabolism from the effector site, I discovered that fatty acid metabolism, and not glycolysis, was upregulated in the peripheral tissue. Fatty acid uptake was enhanced in cells expressing the IL receptor, ST2. These cells highly co-expressed programmed death protein 1 (PD-1), a known regulator of T cell Graham Anthony Heieis.

Apr 01,  · The modern concept of co-stimulation has shed new light on the mechanisms involved in the regulation of T-cell activation and differentiation.

Description Regulation of CD4 T cell differentiation by OX40L PDF

The identification of several new co-stimulatory molecules and their receptors supports the idea of fine-tuning T-cell functions via a multitude of simultaneously or consecutively expressed T-cell Cited by: Nov 08,  · Background/Purpose: Regulatory T cells (Treg) are impaired in human Systemic Lupus Erythematosus (SLE) and contribute to T cell activation.

However, the mechanisms responsible for the Treg deficiency in SLE remain unclear. Our group recently reported that OX40L was expressed by myeloid APCs in blood and in inflamed tissues of SLE patients.Acquisition of self-reactive effector CD4 + T cells is a major component of the autoimmune response that can occur during myocarditis, an inflammatory form of cardiomyopathy.

Although the processes by which self-reactive T cells gain effector function have received considerable attention, how these T cells contribute to effector organ inflammation and damage is less by: 6.